In the evening's main event, two of the world's pound-for-pound greats clash in what is the most anticipated fight of the year in boxing.
Alvarez's biggest fight before this one was a 12-round loss to Mayweather in 2013 in an entertaining fight which Mayweather deserved to win.
But in June, the Mayweather-McGregor fight was announced and the outspoken fighters commanded the media spotlight, helped along by a four-city global media tour that stretched across three countries. The skill and style of both fighters has captured the imagination and sold this fight to the public with notably little trash talk required.
Golovkin is undefeated at 37-0, with 33 knockouts to his name.
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Whatever happens, it promises to be a show-stopping night in Sin City, and we've taken a look at some of the best Opta facts ahead of what will surely go down in the annals as one of the all-time epic contests.
"When I was born, all of the fear had already been given out", he said through a translator, per The Guardian's Bryan Armen Graham. Golovkin, who won a silver medal in the 2004 Olympics, is hoping for the kind of performance that will finally win over fans not overly impressed by a 23-fight knockout streak of 18 middleweight title defenses.
"This is a fight the people have waited for a long time, and I think it's of the same calibre and quality".
Many believe that Erislandy Lara, the Cuban he faced 10 months later, should have been given the win against him, too, instead of losing on a split decision. "I'm happy for all the love from these fans and I'll give them 100 per cent like I always do". Some in boxing thought it showed some vulnerability or suggested that at the age of 35 Triple G is getting a bit old.
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Alvarez will be wary of Golovkin's power, as the latter is known for fighting at higher weight limits.