Arsenal host Leicester City on Friday night, marking the first time in league history the season's first match won't be played on a Saturday.
Substitute Aaron Ramsey rifled home to level before Giroud - introduced alongside the Wales worldwide - headed in an 85th-minute victor to settle a breathless encounter in Arsenal's favour.
Danny Welbeck levelled for Arsenal, but Vardy's second goal looked to have won it for Leicester until the sensational finale.
Alexandre Lacazette is in line to make his first Premier League start and all eyes will be on the Frenchman as he looks to justify the club-record fee Arsenal spent bringing him from Lyon.
He enjoyed a quieter season past year as Leicester finished in mid-table and - despite his new contract - has once again angled for a move away.
Former Arsenal legend Paul Merson believes Arsenal will get off to a winning start this season.
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The fans at the Emirates were getting their first glimpse of Lacazette in a competitive game and the £46.5 million ($60.3 million, 51.1 million euros) man needed less than two minutes to find the net.
It took Lacazette just 94 seconds to score in the Premier League with his second touch in England's top-flight.
But perhaps the answer that baffled Wenger the most was when the German defender said his favourite pet animal was a guinea pig.
Honestly, you could not have asked for more to open the Premier League season for the 2017-18 campaign. It's not like they are going to sell him for £50m and take £200 of everybody's season tickets because we've sold our best player.
Arsenal will be feeling confident ahead of this one as they came from behind to win the Community Shield last weekend against Chelsea on penalties.
It was scruffy end to a sublime move in which Arsenal's players tippy-tapped their way through the Leicester defence with laser-like speed and precision.