"From Monday I will be ready to start again, I'll be ready for a new challenge".
"Roma-Genoa, Sunday 28th May 2017, the last time I can wear Roma's jersey", he posted to his official social media accounts.
The Giallorossi's new director of sport Monchi revealed earlier this month that Totti will retire at the end of the season, but the 40-year-old striker never confirmed it himself, until now.
Totti added: "I can't tell you in a few words how much these colours mean, meant and will always mean to me".
Roma's Francesco Totti claps at the end of their Champions League Group E soccer match against CSKA Moskow at the Olympic Stadium in Rome September 17, 2014. "I'm ready for a new challenge", he said, adding that football was a passion he needed to fuel.
A young Totti also caught the eye of Eriksson before going on to make nearly 800 appearances in all competitions, scoring more than 300 goals.
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Now, another Serie A team has made a move to secure his services on a one-year basis for the 2017/18 season. The Roma manager just happens to be on his way out at the Olimpico, and is heavily linked to Inter Milan.
Totti is also second all-time in goals scored in Serie A with 250, 24 short of the record that Silvio Piola established from 1929-54.
He has spent his entire career at the Rome club, having made his first appearance at senior level as a 16-year-old in 1993.
In 1998 at the age of 22, Totti became the youngest ever Serie A captain.
Appearing for his country at all levels from U15, Totti scored nine goals in 58 senior appearances for Italy before retiring from global football in 2006 after winning the World Cup.