Spurs fans already knew they would be without Danny Rose (knee), Harry Kane (ankle) and Erik Lamela (hip), but Friday's update on TottenhamHotspur.com revealed that Victor Wanyama and Kyle Walker could also miss the game.
Striker Janssen is back in the spotlight with Harry Kane nursing an ankle injury, but the Dutchman faces a fight to rescue a miserable debut season at White Hart Lane.
Because of the global break at the end of the month, Kane might only miss four league matches - against Southampton, Burnley, Swansea and Watford. We have different opportunities to play, use different formations.
"I only express the feeling and the way that we are doing on the training ground".
The news is a "huge boost" for manager Mauricio Pochettino as his side try to maintain the pressure on Chelsea, the runaway Premier League leaders, says The Sun.
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"If you see different players who arrive this season in the Premier League, when you have a striker like Kane who scores goals and plays well, it is hard for your second striker to take his place", he said. We lost Harry Kane for seven to eight weeks and one of the best performances was without him against Manchester City. 'My job is to select only 11 players, but I was always happy with Sonny, ' said Pochettino.
The visitors have had two weeks off and will be looking to end their Premier League campaign on a positive note to ensure a top-half finish.
"We have improved a lot from that period. But with Harry Kane not available we will have the chance to play more".
The most troubling statistic though, ahead of Sunday's Premier League showdown with Southampton, is that without Kane, Spurs' average goal count drops significantly from 2.09 per game to 1. In the system we used in the last few months it has not allowed us to play with two or three strikers. This weekend they welcome Southampton to White Hart Lane; the Saints have recorded back-to-back away wins in high-scoring games, so Tottenham's excellent home record could be under threat.
Any change of style will be in evidence on Sunday, when Tottenham travels to play Southampton in the Premier League. "He's a player we need to be focused on".