The group was first seen performing stunts in the street shortly before driving onto Highway 101 and surrounding a white vehicle, reports the San Francisco Chronicle. When the men began vandalizing his auto, the driver left the vehicle to confront them, which lead to the beating.
The California Highway Patrol said the incident took place at 6:15 p.m. Wednesday on southbound Highway 101 near the Cesar Chavez exit in San Francisco.
The newspaper reports one video shows the Uber driver falling and tumbling as at least two men punched and kicked him.
A local resident who videotaped Wednesday's incident told KNTV-TV one of the bikers swerved toward the motorist - who was driving a white Toyota Camry - and then appeared to fishtail before regaining control of the dirt bike.
The video shows one of the assailants attacking the driver as he rolls backward on the pavement.
When the bikers left, the videographer says he got out of his vehicle to help Alex.
The exact motive for the melee was not immediately clear, but it echoed the infamous attack of a Manhattan dad in Washington Heights in 2013.
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The motorist pulled to the side of the freeway where he was attacked by the bikers. The bump led several in the group to surround Lien's vehicle, and he hit the gas in a panic, plowing over motorcyclist Edwin Mieses and breaking his spine.
Several of the bikers were convicted of assault, including an undercover NY police detective.
Authorities have said it wasn't possible to identify the bikers because the motorcycles had no license plates and the gang members wore helmets.
After the motorist pulled to the side of the freeway, the bikers surrounded his vehicle and struck it with their dirt bikes and their fists, California Highway Patrol Officer Vu Williams told the station.
The men on dirt bikes fled the area before CHP officers arrived on scene, Williams said. His leg was broken in the attack.
His attackers are reportedly hard to trace because none of the bikes appeared to have license plates.