During Perry's elaborately staged spot, she danced among scores of dancers who were dressed as houses.
The "Trump" skeleton wore a red tie and May wore a red blazer and skirt - similar to the outfits the pair wore when they met last month at the White House.
She was a dedicated supporter of Hilary Clinton during the United States president elections and has been critical of Trump since his election.
There's no word yet on whether the dancing house in question emerged unharmed, but based on the video, it seems like their costume mostly broke their fall.
Here's the full list of winners at the Brit Awards 2017. According to Sheeran, he was so sweaty after his performance, Katy Perry would not hug him!
"So comfortable, we're living in a bubble/ So comfortable, we can not see the trouble", Perry sings.
Platte County upgraded to winter storm warning
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Amber Tamblyn Welcomes A Baby Girl With The Wildest (Fake) Name
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Evers, Holtz Advance In Wisconsin Superintendent Race
Evers is completing his second term as the state's top education official in charge of the Department of Public Instruction. Marvin Glass, 81, a retired technical college teacher from the Milwaukee suburb of Brookfield, said he voted for Holtz.
One viewer quipped on Twitter: "An artistic impression of the housing market beginning to crash because of hyper-inflation".
The annual music event is known for its touch of anarchy, but Wednesday night's show - hosted by Dermot O'Leary and Emma Willis - went seemingly without a hitch.
Yep. I warned you that things got really weird really fast. "Bring back 90's era Brits, when pop stars had personalities", one said.
Katy Perry in Adam Selman at the Brit Awards afterparty in London, England, February 2017. Got a little political as well.
Skepta and Little Mix led the nominations with three each. Bowie, who was honored at last year's ceremony in a tribute featuring Lorde's version of "Life on Mars," is also nominated for British Male Solo Artist.
For some, a BRIT Awards "horror story" might comprise of an embarrassing wardrobe malfunction, unexpected stage invasion or a spectacular tumble mid-performance.