During Perry's elaborately staged spot, she danced among scores of dancers who were dressed as houses.
The "Trump" skeleton wore a red tie and May wore a red blazer and skirt - similar to the outfits the pair wore when they met last month at the White House.
She was a dedicated supporter of Hilary Clinton during the United States president elections and has been critical of Trump since his election.
There's no word yet on whether the dancing house in question emerged unharmed, but based on the video, it seems like their costume mostly broke their fall.
Here's the full list of winners at the Brit Awards 2017. According to Sheeran, he was so sweaty after his performance, Katy Perry would not hug him!
"So comfortable, we're living in a bubble/ So comfortable, we can not see the trouble", Perry sings.
Korean leader Kim assassinated in Malaysia: Yonhap
The Indonesian woman has told investigators that she was duped into thinking she was part of a comedy show prank. Police have already arrested four people in connection with the attack, including the two women.
Combatting Terrorism: French Military Training Eagles For Drone Defense
The birds begin with flights in a straight line, graduating to diving from a height. "I don't want to send them to their death". Another brood of eagles has been approved by the French government, according to Agence France-Presse.
Oscar Awards 2017: Our Predictions for the 89th Academy Awards winners
You may have heard that La La Land scooped up 14 nominations and that Moonlight was the best-reviewed film of the year. This just might be the best week of the year to cozy in and watch a new movie on DVD or Blu-ray.
One viewer quipped on Twitter: "An artistic impression of the housing market beginning to crash because of hyper-inflation".
The annual music event is known for its touch of anarchy, but Wednesday night's show - hosted by Dermot O'Leary and Emma Willis - went seemingly without a hitch.
Yep. I warned you that things got really weird really fast. "Bring back 90's era Brits, when pop stars had personalities", one said.
Katy Perry in Adam Selman at the Brit Awards afterparty in London, England, February 2017. Got a little political as well.
Skepta and Little Mix led the nominations with three each. Bowie, who was honored at last year's ceremony in a tribute featuring Lorde's version of "Life on Mars," is also nominated for British Male Solo Artist.
For some, a BRIT Awards "horror story" might comprise of an embarrassing wardrobe malfunction, unexpected stage invasion or a spectacular tumble mid-performance.